SIM BFI-HR-Yeeran | Preclinical instruments

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SIM BFI-HR

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Product Introduction

SIM BFI HR Laser Speckle Imaging Systemis designed based on the new LSCI (Laser Speckle Contrast Imaging / LSCI) technology, with unique non-contact, high temporal and spatial resolution and technical advantages of full-field fast imaging，which provides a real-time dynamic blood flow monitoring and video imaging recording method for basic research in life sciences and clinical medicine. It is a vital basis for understanding tissue, organ pathology or physiological indicators. The instrument does not require any contrast agent, the time resolution can reach the order of milliseconds and the spatial resolution can reach the order of micrometers, which realizes the real-time observation of blood flow distribution status of microvascular and functional requirements for relative changes in blood flow values.

Real-Time Imaging/High Spacial Resolution/Large View/Non-contact/Non-destructive

SIM Blood Flow Imager has offered a real-time method for acquiring and recording the blood perfusion images, which is a key way to learn the pathological or physiological parameters of issue or organs for life science basic research and clinic research. SIM BFI -HR imager has the specific advantages of non-contact, real-time imaging, high spacial resolution,

large view field and no contrast agent, which is based on the latest technology of LASER SPECKLE CONTRAST IMAGING. The spacial resolution of the blood flow imaging could be up to millisecond level, and the temporal resolution could be up to micrometer level. By using SIM BFI imager, the distribution of the micro blood vessels and the relative change of the blood flow value can be observed and analyzed, which is significant for doctors or researchers.

Product Features

High temporal/spacial resolution，high contrast
Non-contact，No contast agent
Full field，no scan
Multi-outputs: image, video, blood flow value, vessel diameter

Performance Advantages

1. acquire the blood flow images in real time with micrometer resolution, and advance the accuracy of the blood flow value by correcting the interference of static scattering or multi-scattering

2. Analyze the blood flow mean value of the region of interest(ROI) and vessel diameter value online or offline, and analyze the blood flow mean value and standard deviation of the time of interest(TOI) offline, moreover, any shape and quantity of ROIs could be drawed, and the position and size of any ROI could be adjusted freely

3. The blood flow imaging speed could be achieve 60 fps even though in the condition of maximum pixels

4. The optical magnification could be read directly without calculation

5. Multi-format could be choosed for recording, like raw data/.jpg/.bmp/.png /.avi and so on

6. When record images, you could choose to image continuously or with a specific interval

7. A excellent system stabilization could be achieved based on high-coherence laser illuminating and high-performance 12-bit camera acquiring

8. A whole acquiring and analyzing plan and sale-service could be offered

Technique parameter

Laser type:laser diode

Laser wavelength: 785nm

Laser control: constant current and constant temperature

Image size:2048*1536

Working distance: 200mm

Magnification: 0.335-2.25*

View field: 6.31*4.71mm-42.2*31.6mm

Spacial resolution of blood perfusion imaging: up to 3μm/pixel

Temporal resolution of blood perfusion imaging: up to 60fps

Analysis parameter: blood perfusion value, blood diameter value, blood perfusion mean value of ROI, blood perfusion mean value and standard deviation of TOI

ROI: any shape and quantity, position and size could be adjusted freely

record mode: continuously or with specific intervals

Record format: raw data, image like .jpg/.bmp/.png or video like .avi

Software function: register blood flow image and structural image, mark the special event during recording, record and load the analysis parameter, draw the grid for locating the object and so on.

Application examples

Cortical blood flow imaging of tree shrew (nonhuman primate)

(a) normal cortical blood flow distribution (b) At the early time of over anesthesia (c) At the end time of over anesthesia

MCAO

Photochemical ischemia

Skin window

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